AENDO October 40/4
نویسنده
چکیده
Goodwin, Gary W., and Heinrich Taegtmeyer. Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E772–E777, 1999.—We tested the hypothesis that the level of malonyl-CoA, as well as the corresponding rate of total fatty acid oxidation of the heart, is regulated by the opposing actions of acetyl-CoA carboxylase (ACC) and malonyl-CoA decarboxylase (MCD). We used isolated working rat hearts perfused under physiological conditions. MCD in heart homogenates was measured specifically by CO2 production from [3-14C]malonyl-CoA, and ACC was measured specifically based on the portion of total carboxylase that is citrate sensitive. Increased heart work (1 μM epinephrine 1 40% increase in afterload) elicited a 40% increase in total b-oxidation of exogenous plus endogenous lipids, accompanied by a 33% decrease in malonyl-CoA. The basal activity and citrate sensitivity of ACC (reflecting its phosphorylation state) and citrate content were unchanged. AMP levels were also unchanged. MCD activity, when measured at a subsaturating concentration of malonyl-CoA (50 μM), was increased by 55%. We conclude that physiological increments in AMP during the work transition are insufficient to promote ACC phosphorylation by AMP-stimulated protein kinase. Rather, increased fatty acid oxidation results from increased malonyl-CoA degradation by MCD.
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AENDO October 40/4
Solano, Joel M., and Lauren Jacobson. Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E708–E716, 1999.—Glucocorticoid stimulation of appetite and leptin expression conflicts with leptin inhibition of food intake and suggests that glucocorticoids reduce sensitivity to leptin. To determine if gluc...
متن کاملAENDO October 40/4
Mosoni, L., T. Malmezat, M. C. Valluy, M. L. Houlier, D. Attaix, and P. Patureau Mirand. Lower recovery of muscle protein lost during starvation in old rats despite a stimulation of protein synthesis. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E608–E616, 1999.—Sarcopenia could result from the inability of an older individual to recover muscle lost during catabolic periods. To test this hypoth...
متن کاملAENDO December 40/6
WIM DERAVE,1,2 STEN LUND,3 GEOFFREY D. HOLMAN,4 JØRGEN WOJTASZEWSKI,1 OLUF PEDERSEN,5 AND ERIK A. RICHTER1 1Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, 2100 Copenhagen; 5Steno Diabetes Center and Hagedorn Research Institute, 2820 Gentofte, Copenhagen; 3Medical Research Laboratory, Aarhus Kommunehospital, 8000 Aarhus, Denmark; 2Department of Movement and ...
متن کاملAENDO October 40/4
Rong, Pei, Jennifer L. Wilkinson-Berka, and Sandford L. Skinner. Potassium control of extrarenal renin secretion in transgenic (mRen-2)27 and normal rats. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E631–E638, 1999.— Plasma active renin and prorenin were followed for 12 h after bilateral, unilateral, and sham nephrectomy (BNx, UNx, and SNx) in anesthetized transgenic (mRen-2)27 rats to compare...
متن کاملAENDO October 40/4
Mauras, Nelly, Valerie Quarmby, and Duane C. Bloedow. Pharmacokinetics of insulin-like growth factor I in hypopituitarism: correlation with binding proteins. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E579–E584, 1999.—We investigated the pharmacokinetics of recombinant human insulin-like growth factor I (rhIGF-I) in growth hormone deficiency (GHD). Nine GHD adults [age 25 6 3 (SE) yr] receive...
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